Revival came during the reign of Hezekiah but it was immediately swept aside by his son Manasseh, who was Judah's most wicked and longest ruling king. The nation never fully recovered from the effects of this evil king. Manasseh's son Amon continued in his father's depravity, but he soon was murdered. His successor Josiah (about 640-609 B.C.) restored traditional covenant religion, which was based on the Book of the Law newly discovered in a Temple storeroom (2 Chr. 34:14). Many did not follow Josiah's example, however, and the prophet Zephaniah foretold disaster for the nation. By 610 B.C. the Assyrian Empire had collapsed under Babylonian attacks, and Babylon prepared to march against Egypt, which had been helping the Assyrians. Against Jeremiah's advice, Josiah intervened and was killed at Megiddo.

After Josiah there was no hope for Judah, the last 3 kings were all evil. The Babylonians swept down upon Jerusalem in 597 B.C. and captured it. A second attack led to Jerusalem's second defeat in 586 B.C. Captives from both campaigns were taken to Babylonia to mark the captivity of the Southern Kingdom.

Around 605 B.C. Nineveh and Assyria had fallen. It was just Egypt and Babylon who were seeking world supremacy. The young brilliant new king of Babylon, Nebuchadnezzar, went out and defeated the Egyptians at Carchemish. He marched on to Judah, during Jehoiakim's reign, and took thousands of Hebrews back to Babylon (including Daniel, who became one of the greatest prophets). Nebuchadnezzar made two more attacks when he heard of rebellion in Judah. Each time he took captives (including Ezekiel the prophet). Only a remnant of the weakest, poorest, and least threatening Jews remained. King Nebuchadnezzar set up a puppet king (Zedekiah) of David's line to sit on the throne of Judah and made him swear an oath of allegiance (2 Chr 36:10-12).

Zedekiah was as faithless as the rest of the evil kings of Judah. He then rebelled and allied with other enemies. When Nebuchadnezzar heard he came back for the last time (586 B.C.) to reduce Jerusalem to rubble and send the Temple up in flames. Zedekiah was forced to witness the slaughter of his sons, then his eyes were put out, and he himself was carried off to Babylon. The Kingdom was over and the "times of the gentiles" had begun.